ABSTRACT
Children under 5 years of age in developing countries are particularly vulnerable to malnutrition. Malnutrition affects 50% of hospitalized children and 25–70% of the critically ill children. Malnutrition interferes with the appropriate response of the body to disease and predisposes to infection and to the onset of multiorgan failure, increasing morbidity and mortality, the mean length of hospital stay, and health costs. Aim: A prospective cohort study of children admitted to the tertiary pediatric ICU between January 2009 and January 2014 was carried out. To assess the malnutrition type, and impact of nutritional status on outcomes like mortality rate, disease, complication in critically ill children.To the study were enrolled 138 children admitted to the pediatric intensive care units of the NationalCenter for Maternal and Childrens Hospital. The study protocol was approved by the Ethics Committee of the MNUMS, and written informed consent was obtained from all study participants. Nutritional status was determined using Waterlow criteria.Total participants were 49.3% (n=68) of male, 50.7% (n=70) female. 138 children with a mean age 4.4 months ±3.6/ Std.Er/, min = 1 month, max = 12 months, mode = 1 month. n=70(50.7%) acute malnutrition, n=58(42%) chronic malnutrition by Waterlow criteria. In malnutrition group was assessed patient with ricket n=36 (26.1%), patient with anemia n=56(58.9%)While malnutrition is a major problem in pediatric intensive care units. Acute malnutrition moreoccurred in the pediatric intensive care.Malnutrition more occurring of intrauterine infection, genetic disorder, hematology disease’s patients.
ABSTRACT
Introduction: In many cases of aethelogy the gut microflore of gastrointestinal tract change by quantity, quality and structure then mainly occurred propagation and increase informal microflore. And that is the cause of aggravation of dysbacteriosis. In dysbacterios species and number of gut microflore of gastrointestinal tract increasing year by year and information of prior unsearched microflores are being increased.Especially, changing level in gut microbiota after Helicobacter pylori eradication therapy of chronic gastro duodenal disorder has not studied yet in the field, pediatric gastroenterology in Mongolia.Objective: To determine the effects on normal gastrointestinal microbiota after eradication therapy of Helicobacter pylori for chronic gastro duodenal disorder.Materials and Methods: A prospective cohort study of 50 patients, average age 12.82±2.9, during two years period from 2009-2010, evaluating the gut microbiota after Helicobacter pylori eradication therapy of chronic gastro duodenal disorder in Gastroenterology Unit, Maternal and Child Research Health Center.Results: Of the 50 patients there were 16 (32%) with peptic ulcer and 34 (68%) chronic gastroduodenitis due to Helicobacter pylori infection. The triple treatments were used in 34 cases (68%), the quartile treatment used in 16 cases (32%) and the probiotic combination therapy used in 27 cases (54%). After Helicobacter pylori eradication therapy, the H pylori serology test was positive in 9 cases (18%) and negative in 41 cases (82%). Before Helicobacter pylori eradication therapy, 45 cases (90%) had abnormal gut microbiota, 5 cases (10%) had normal gut microbiota. After eradication therapy with a probiotic, 19 cases (70%) had normal gut microbiota.Conclusion: After Helicobacter pylori eradication therapy there was an alteration in normal gut microbiota. The probiotic combination therapy was more effective in establishing normal gut microbiota than the non-probiotic combination therapy.